Particle collisions at energies well above the Planck scale are believed to be dominated by the production of black holes. If the fundamental Planck scale is of order a TeV, as suggested in certain theories with large extra dimensions, microscopic black holes may be produced at the Large Hadron Collider at a rate of up to 1 Hz. Black hole production and decay leads to very dramatic events with a cross section which grows with a power of the energy. Standard hard scattering processes such as Drell-Yan or QCD jet production are also exponentially suppressed. Observation of these signatures would provide an experimental confirmation of the infrared--ultraviolet nature of quantum gravity, and herald the end of experimental investigation of short distances by high energy scattering.