Several analyses performed in IceCube are motivated by Fermi-LAT observations. Diffuse gamma-rays from the galactic plane have been measured by Fermi-LAT and compared to models which include contributions form pion decay, bremsstrahlung, and inverse Compton scattering. The pion contribution would produce a similar pattern of neutrino emission. IceCube’s galactic plane analysis searches for diffuse neutrinos using the Fermi-LAT model as a spatial template to maximize sensitivity and to set an upper limit on neutrino production, and thus, on pion production. Another feature observed in the Fermi-LAT data is the Fermi bubbles. If the observed gamma-rays are produced via hadronic interactions, a similar neutrino emission should be seen in IceCube. IceCube data can already be used to constrain the fraction of these gamma-rays that are hadronic in origin. Other results that will be presented include the stacking analysis of Fermi point sources that have high-energy gamma-ray observations and supernova remnants with molecular cloud associations.